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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB3
All Species:
40.91
Human Site:
Y58
Identified Species:
81.82
UniProt:
Q16875
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16875
NP_001138915.1
520
59609
Y58
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Chimpanzee
Pan troglodytes
XP_001147864
523
59913
Y58
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Rhesus Macaque
Macaca mulatta
XP_001107535
520
59589
Y58
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Dog
Lupus familis
XP_544267
559
63551
Y71
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
Y64
V
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Rat
Rattus norvegicus
O35552
555
63657
Y58
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
Y124
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Chicken
Gallus gallus
Q91348
470
54386
Y63
I
S
R
K
L
T
R
Y
L
N
W
I
G
M
P
Frog
Xenopus laevis
NP_001088535
470
54750
Y63
I
S
K
K
L
T
R
Y
L
N
W
I
G
I
P
Zebra Danio
Brachydanio rerio
NP_998562
536
62010
Y61
M
S
R
K
L
T
R
Y
L
N
W
I
G
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
C50
T
Y
I
S
K
K
L
C
R
Y
L
K
W
T
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
K45
S
W
L
S
I
K
A
K
C
F
N
V
G
N
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
99.6
84.6
N.A.
65.5
89.9
N.A.
76.6
61.1
65.5
72.3
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
97.1
99.8
87.6
N.A.
77.8
91.7
N.A.
84.2
77.1
76.7
84.1
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
100
86.6
93.3
80
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
92
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
67
0
9
0
9
0
0
0
0
0
0
84
0
17
0
% I
% Lys:
0
0
67
84
9
17
0
9
0
0
0
9
0
0
0
% K
% Leu:
0
0
9
0
84
0
9
0
84
0
9
0
0
0
0
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
84
9
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
84
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
17
0
0
0
84
0
9
0
0
0
0
0
0
% R
% Ser:
9
84
0
17
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
9
0
0
0
0
84
0
0
0
0
0
0
0
9
0
% T
% Val:
9
0
0
0
0
0
0
0
0
0
0
9
0
59
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
84
0
9
0
0
% W
% Tyr:
0
9
0
0
0
0
0
84
0
9
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _